Sidney Ponson (2-0, 3.31) takes the start for the St. Louis Cardinals (14-7) while Mike O'Conner makes his season debut for the Washington Nationals (7-14).
All-time, the Cardinals are 268-262 in the series. Last season, the Cardinals took four of six from them. This season is the first since 1969 that the Cardinals did not have to take a trip across the border, the longest streak in baseball.
Jason Marquis is presented his Silver Slugger before the game. Bill DeWitt, Jr., will honor Albert Pujols with a specially designed watch.